RESUMO
Introducción. La condición nutricional de la mujer antes y durante el embarazo es uno de los determinantes del riesgo de morbimortalidad materna. Objetivo. Determinar la relación del incremento del índice de masa corporal y la presencia de infección de las vías urinarias en primigestas. Métodos. Estudio de casos y controles en expedientes de primigestas. Se estudiaron variables sociodemográficas (edad, escolaridad, vida en pareja y ocupación), condiciones obstétricas (riesgo obstétrico, semanas de inicio del control prenatal, semanas de resolución del embarazo y número de consultas prenatales), antropometría al inicio y al final del embarazo (peso, talla, índice de masa corporal y condición nutricional -peso bajo, peso normal, sobrepeso y obesidad-, ganancia de peso y ganancia de índice de masa corporal) y modificación de la condición nutricional al inicio y al final del embarazo. El análisis estadístico se efectuó con porcentajes, promedios, intervalos de confianza para promedios, prueba de chi2, razón de momios, intervalos de confianza para razón de momios, regresión lineal simple y proyección de la ocurrencia del evento. Resultados. Cuando el incremento del índice de masa corporal fue de 5 kg/m2, el promedio de infección de las vías urinarias correspondió a 1,62 y, si el incremento del índice de masa corporal fue 10 kg/m2, el promedio de infección de las vías urinarias fue 2,3. Conclusión. En nuestro estudio, a mayor incremento del índice de masa corporal durante el embarazo de la primigesta, mayor fue su probabilidad de presentar infección de las vías urinarias.
Introduction: The nutritional status of women before and during pregnancy is one of the determinants of the risk of maternal morbidity and mortality. Objective: To determine the relationship between the increase in body mass index and the presence of urinary tract infection in primigravidae. Methods: Case-control study in primigravidae records. We studied sociodemographic variables (age, schooling, life as a couple and occupation), obstetric conditions (obstetric risk, weeks of beginning of prenatal control, weeks of pregnancy resolution and number of prenatal visits), anthropometry at the beginning and end of pregnancy (weight, height, body mass index and nutritional condition -underweight, normal weight, overweight and obesity-, weight gain and body mass index gain), and modification of nutritional condition at the beginning and end of pregnancy. Statistical analysis was performed with percentages, averages, confidence intervals for averages, Chi2 test, odds ratio, confidence intervals for odds ratio, simple linear regression, and projection of event occurrence. Results: When the increase in body mass index was 5 kg/m2, the mean urinary tract infection corresponded to 1.62 and, if the increase in body mass index was 10 kg/m2, the mean urinary tract infection was 2.3. Conclusion: In our study, the greater the increase in body mass index during pregnancy of the primigravida, the greater her probability of presenting urinary tract infection.
RESUMO
The toxicity profiles of the phenyl alcohol amides: 4-hydroxy, 4-ethyl, 4-phenylbutyramide (HEPB) and two lower homologous: 3-hydroxy, 3-ethyl, 3-phenylpropionamide (HEPP) and 2 hydroxy, 2-ethyl, 2-phenylacetamide (HEPA) were studied in mice. TD50 value was determined by oral administration and LD50 by oral and intraperitoneal routes. The results indicate that HEPP is less toxic than the others, both of which had very similar toxicity. Furthermore, the teratogenic potential of HEPB was investigated in mice after oral administration. The compound was administered on days 6 - 15 of gestation at doses of 0, 5, 25, 50 or 100 mg/kg of weight. On day 17 of pregnancy the mice were sacrifed and the pups examined. An increase of body weight in both mothers and fetuses was observed at 25 and 50 mg/kg, as a sign of maternal toxicity. Considering the litter data, embryotoxicity and fetotoxicity were only shown at the highest dose. Howeever, the HEPB treatment did not result in malformations of live fetuses or resorptions when the implantations were considered as the individual entity